1-Docosanol
Names
[ CAS No. ]:
661-19-8
[ Name ]:
1-Docosanol
[Synonym ]:
Emery 3304
MFCD00002939
Docosanol
ALCOHOL C22
tadenan
lidavol
IK 2 (alcohol)
n-docosanol
behenic alcohol
Docosanol (Abreua)
behenyl alcohol
ik2
docosanyl alcohol
docosan-1-ol
Abreva
Lidakol
1-Docosanol
EINECS 211-546-6
JARCOL 22
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
0.8±0.1 g/cm3
[ Boiling Point ]:
375.9±5.0 °C at 760 mmHg
[ Melting Point ]:
65-72 °C(lit.)
[ Molecular Formula ]:
C22H46O
[ Molecular Weight ]:
326.600
[ Flash Point ]:
142.5±5.2 °C
[ Exact Mass ]:
326.354858
[ PSA ]:
20.23000
[ LogP ]:
10.44
[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C
[ Index of Refraction ]:
1.455
[ Storage condition ]:
2-8°C
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
Insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JR1315000
- CHEMICAL NAME :
- 1-Docosanol
- CAS REGISTRY NUMBER :
- 661-19-8
- BEILSTEIN REFERENCE NO. :
- 1770470
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C22-H46-O
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T2018 No. of Facilities: 151 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1358 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
-
[ RTECS ]:
JR1315000
[ HS Code ]:
29051900
Synthetic Route
Customs
[ HS Code ]: 29051900
Articles
J. Sci. Ind. Res. 65(10) , 808, (2006)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...
Surface properties of artificial tear film lipid layers: effects of wax esters.Invest. Ophthalmol. Vis. Sci. 55(7) , 4448-54, (2014)
The tear film lipid layer is believed to stabilize the tear film and to retard evaporation. Based on previous simple in vitro studies, the evidence for the latter property is scarce. In this study, we...
Bioactive constituents in Prunus africana: geographical variation throughout Africa and associations with environmental and genetic parameters.Phytochemistry 83 , 70-8, (2012)
Prunus africana--an evergreen tree found in Afromontane forests--is used in traditional medicine to cure benign prostate hyperplasia. Different bioactive constituents derived from bark extracts from 2...