Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester

Names

[ Name ]:
Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester

[Synonym ]:
HMS2882B21
2'-nitrobenzylidenemalonic acid dimethyl ester
dimethyl 2-nitrobenzylidenemalonate
ortho-nitrobenzylidenmalonsaeuredimethylester

Biological Activity

[Description]:

NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Inflammation/Immunology

[References]

[1]. Zhang S, et, al. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem. 2012 Oct 15;20(20):6073-9.

Chemical & Physical Properties

[ Density]:
1.335g/cm3

[ Boiling Point ]:
361.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₁NO₆

[ Molecular Weight ]:
265.21900

[ Flash Point ]:
151.8ºC

[ Exact Mass ]:
265.05900

[ PSA ]:
98.42000

[ LogP ]:
1.84740

[ Index of Refraction ]:
1.578

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.