Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester

Names

[ Name ]:
Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester

[Synonym ]:
HMS2882B21
2'-nitrobenzylidenemalonic acid dimethyl ester
dimethyl 2-nitrobenzylidenemalonate
ortho-nitrobenzylidenmalonsaeuredimethylester

Biological Activity

[Description]:

NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Inflammation/Immunology

[References]

[1]. Zhang S, et, al. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem. 2012 Oct 15;20(20):6073-9.

Chemical & Physical Properties

[ Density]:
1.335g/cm3

[ Boiling Point ]:
361.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₁NO₆

[ Molecular Weight ]:
265.21900

[ Flash Point ]:
151.8ºC

[ Exact Mass ]:
265.05900

[ PSA ]:
98.42000

[ LogP ]:
1.84740

[ Index of Refraction ]:
1.578

Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream