Necrostatin-1

Names

[ Name ]:
Necrostatin-1

[Synonym ]:
5-Indol-3-ylmethyl-2-thioxo-imidazolidin-4-on
IN1206
Necrostatin-1,Inactive Control
5-indol-3-ylmethyl-2-thioxo-imidazolidin-4-one
Thiohydantoin-Try
Tryptophanthiohydantoin
Nec-1i
tryptophan 2-thiohydantoin

Biological Activity

[Description]:

Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Degterev A, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May;4(5):313-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₁N₃OS

[ Molecular Weight ]:
245.30000

[ Exact Mass ]:
245.06200

[ PSA ]:
99.54000

[ LogP ]:
1.20610

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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