L189

Names

[ Name ]:
L189

[Synonym ]:
6-Amino-5-[(E)-benzylideneamino]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone
6-Amino-5-{[(E)-phenylmethylene]amino}-2-sulfanylpyrimidin-4-ol
4-pyrimidinol, 6-amino-2-mercapto-5-[[(1E)-phenylmethylene]amino]-
6-amino-5-benzylideneamino-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
6-amino-5-(benzylideneamino)-2-sulfanyl-4-pyrimidinol
6-Amino-5-[(E)-benzylideneamino]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-5-[[(1E)-phenylmethylene]amino]-2-thioxo-
L-189
L189

Biological Activity

[Description]:

L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.IC50 value: 5/9/5 μM (for hLigI/III/IV)Target: DNA ligasein vitro: L189 is a competitive inhibitor with respect to nicked DNA. L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non-homologous end joinging. L189 markedly increases killing of HCT116 colon cancer cells and the other cancer cell lines by ionizing radiation.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Research Areas >> Cancer

[References]

[1]. Xi Chen, Shijun Zhong, Xiao Zhu, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₁H₁₀N₄OS

[ Molecular Weight ]:
246.288

[ Exact Mass ]:
246.057526

[ PSA ]:
123.19000

[ LogP ]:
0.32

[ Index of Refraction ]:
1.726

[ Storage condition ]:
2-8℃