Sedanolide

Names

[ Name ]:
Sedanolide

[Synonym ]:
Neocnidilide
3-butyl-3a,4,5,6-tetrahydro-3H-isobenzofuran-1-one
Sedanolide
MFCD00171327

Biological Activity

[Description]:

Sedanolide, a natural compound occurring in edible umbelliferous plants, possesses anti-inflammatory and antioxidant activities[1][2].

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Inflammation/Immunology

[In Vitro]

Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells[2].

[In Vivo]

Sedanolide increases the activity of glutathione-S-transferase (GST) in the liver, small intestinal mucosa, and forestomach of A/J mice[1].

[References]

[1]. J A Woods， et al. Sedanolide, a Natural Phthalide From Celery Seed Oil: Effect on Hydrogen Peroxide and Tert-Butyl Hydroperoxide-Induced Toxicity in HepG2 and CaCo-2 Human Cell Lines. In Vitr Mol Toxicol. Fall 2001;14(3):233-40.

[2]. Shu-Ling Hsieh, et al. Sedanolide Induces Autophagy Through the PI3K, p53 and NF-κB Signaling Pathways in Human Liver Cancer Cells. Int J Oncol. 2015 Dec;47(6):2240-6.

Chemical & Physical Properties

[ Density]:
1.03

[ Boiling Point ]:
342.0±11.0 °C(Predicted)

[ Melting Point ]:
120 °C

[ Molecular Formula ]:
C₁₂H₁₈O₂

[ Molecular Weight ]:
194.27000

[ Exact Mass ]:
194.13100

[ PSA ]:
26.30000

[ LogP ]:
2.82850

[ Index of Refraction ]:
1.742

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36

Related Compounds

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