Allomatrine

Names

[ CAS No. ]:
641-39-4

[ Name ]:
Allomatrine

[Synonym ]:
13S-HYDROXY-6Z,9Z,11E-OCTADECATRIENOIC ACID
4-(2-Biphenylyl)-1-(hydroxymethyl)-10-oxa-4-azatricyclo[5.2.1.0]dec-8-ene-3,5-dione
13-hydroxy-(6Z,9Z,11E,13S)-6,9,11-octadecatrienoic acid
13(S)-HYDROXY-9(Z),11(E),15(Z)-OCTADECATRIENOIC ACID
(13S,6Z,9Z,11E)-hydroxyoctadeca-6,9,11-trienoic acid
Allomatrine
13-hydroxy-6,9,11-octadecatrienoic acid
4,7-Epoxy-1H-isoindole-1,3(2H)-dione, 2-[1,1'-biphenyl]-2-yl-3a,4,7,7a-tetrahydro-4-(hydroxymethyl)-
(+)-Allomatrin
13(S)-HOT
13(S)-HYDROXYOCTADECA-6Z,9Z,11E-TRIENOIC ACID
13(S)-HOTE
(6Z,9Z,11E)-13(S)-hydroxyoctadeca-6,9,11-trienoic acid

Biological Activity

[Description]:

Allomatrine ((+)-Allomatrine) is an alkaloid from the bark of Sophora japonica. Allomatrine has antinociceptive properties mediated mainly through the activation ofκ-opioid receptors[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Long Pan, et al. Chemical Constituents of Alkaloids From the Bark of Sophora Japonica. Zhong Yao Cai. 2016 Sep;39(9):2027-9.

[2]. Seiichi Kobashi , et al. Antinociceptive Effects of 1-acyl-4-dialkylaminopiperidine and 1-alkyl-4-dialkylaminopiperidine in Mice: Structure-Activity Relation Study of Matrine-Type Alkaloids. Biol Pharm Bull. 2002 Aug;25(8):1030-4.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
638.7±55.0 °C at 760 mmHg

[ Melting Point ]:
106-107 â„ƒ

[ Molecular Formula ]:
C₁₅H₂₄N₂O

[ Molecular Weight ]:
347.364

[ Flash Point ]:
340.1±31.5 °C

[ Exact Mass ]:
347.115753

[ PSA ]:
66.84000

[ LogP ]:
2.09

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.666

[ Storage condition ]:
2-8C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.