H-Gly-Gly-Gly-Gly-OH

Names

[ CAS No. ]:
637-84-3

[ Name ]:
H-Gly-Gly-Gly-Gly-OH

[Synonym ]:
MFCD00008129
2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetic acid
EINECS 211-303-4

Biological Activity

[Description]:

Tetraglycine is a oligopeptide composed of four glycine monomers[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vivo]

Tetraglycine and Triglycine (1.0 μmol glycine/g body wt, injected into a central vein) results in greater glycine concentration in the kidney than injection of either Glycine (HY-Y0966) or Diglycine[1]. Animal Model: Male Sprague-Dawley rats (270-300 g)[1] Dosage: 1.0 μmol glycine/g body wt Administration: IV, injected over a period of 30 s Result: Five minutes after the Tetraglycine injection, there were accumulations of diglvcine, triglvcine, and Tetraglycine in the kidney.

Chemical & Physical Properties

[ Density]:
1.393g/cm3

[ Boiling Point ]:
800.9ºC at 760 mmHg

[ Melting Point ]:
300 °C

[ Molecular Formula ]:
C₈H₁₄N₄O₅

[ Molecular Weight ]:
246.22100

[ Flash Point ]:
438.2ºC

[ Exact Mass ]:
246.09600

[ PSA ]:
150.62000

[ Index of Refraction ]:
1.535

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Clostridium difficile sortase recognizes a (S/P)PXTG sequence motif and can accommodate diaminopimelic acid as a substrate for transpeptidation.

FEBS Lett. 588(23) , 4325-33, (2014)

Covalent attachment of surface proteins to the cell wall of Gram-positive bacteria requires a sortase-mediated transpeptidation reaction. In almost all Gram-positive bacteria, the housekeeping sortase...

Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents.

Bioorg. Med. Chem. Lett. 18 , 5512-7, (2008)

Tetrapeptides derived from glycine and beta-alanine were hooked at the C-3beta position of the modified cholic acid to realize novel linear tetrapeptide-linked cholic acid derivatives. All the synthes...

Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.

J. Med. Chem. 49 , 3636-44, (2006)

The human intestinal oligopeptide transporter (PEPT1) facilitates the absorption of dipeptides, tripeptides, and many peptidomimetic drugs. In this study, a large number of peptides were selected to i...