Etersalate

Names

[ CAS No. ]:
62992-61-4

[ Name ]:
Etersalate

[Synonym ]:
Etersalate
Daital
EINECS 263-780-3
Eterilate
Etherylate
Eterylate

Biological Activity

[Description]:

Etersalate inhibits platelet function and decreases thromboxane A2 (TXA2) levels.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

Research Areas >> Cardiovascular Disease

[Target]

TXA2

[In Vitro]

Ex vivo antiplatelet properties of Etersalate and its effects on serum thromboxane A2 (TXA2) levels and prostaglandin I2 (PGI2) generation are studied in human volunteers at two levels of oral dosing. Etersalate inhibits at the lower dosage platelet function and decreased TXA2 levels, but PGI2 generation from rat aortic rings is stimulated when incubated with plasma from Etersalate-treated donors. Blood coagulation parameters remain within normal values. Etersalate administration can act on platelet arachidonate metabolism at a different level than that of the cyclooxygenase pathway[1].

[References]

[1]. Ortega MP, et al. Effect of etersalate on human platelet responsiveness. A study in healthy volunteers. Arzneimittelforschung. 1987 Feb;37(2):214-7.

[Related Small Molecules]

Dinoprostone | Prostaglandin E1 | E7046 | ONO-AE3-208 | PF 04418948 | Fevipiprant | grapiprant | TG6-10-1 | Taprenepag | GW 627368 | MRE-269 | Ramatroban | AH 6809 | Laropiprant | AZD1981

Chemical & Physical Properties

[ Density]:
1.263g/cm3

[ Boiling Point ]:
561.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₉NO₆

[ Molecular Weight ]:
357.35700

[ Flash Point ]:
293.6ºC

[ Exact Mass ]:
357.12100

[ PSA ]:
90.93000

[ LogP ]:
2.87910

[ Index of Refraction ]:
1.582

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG0929000

CHEMICAL NAME :: Benzoic acid, 2-(acetyloxy)-, 2-(4-(acetylamino)phenoxy)ethyl ester

CAS REGISTRY NUMBER :: 62992-61-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H19-N-O6

MOLECULAR WEIGHT :: 357.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4014921

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AFTOD7 Archivos de Farmacologia y Toxicologia. (Universidad Complutense, Facultad de Medicina, Departamento Coordinado de Farmacologia, Ciudad Universitaria, Madrid 3, Spain) V.1- 1975- Volume(issue)/page/year: 4,167,1978

Safety Information

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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