62992-61-4

62992-61-4 structure

62992-61-4 structure

Name: Etersalate
Chemical Name: 2-(4-acetamidophenoxy)ethyl 2-acetyloxybenzoate
CAS Number: 62992-61-4
Molecular Formula: C₁₉H₁₉NO₆
Molecular Weight: 357.35700
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2018-03-03 08:00:00
Modify Date: 2024-01-14 15:11:18
Etersalate inhibits platelet function and decreases thromboxane A2 (TXA2) levels.

Name	2-(4-acetamidophenoxy)ethyl 2-acetyloxybenzoate
Synonyms	Etersalate Daital EINECS 263-780-3 Eterilate Etherylate Eterylate

Description	Etersalate inhibits platelet function and decreases thromboxane A2 (TXA2) levels.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Cardiovascular Disease
Target	TXA2
In Vitro	Ex vivo antiplatelet properties of Etersalate and its effects on serum thromboxane A2 (TXA2) levels and prostaglandin I2 (PGI2) generation are studied in human volunteers at two levels of oral dosing. Etersalate inhibits at the lower dosage platelet function and decreased TXA2 levels, but PGI2 generation from rat aortic rings is stimulated when incubated with plasma from Etersalate-treated donors. Blood coagulation parameters remain within normal values. Etersalate administration can act on platelet arachidonate metabolism at a different level than that of the cyclooxygenase pathway[1].
References	[1]. Ortega MP, et al. Effect of etersalate on human platelet responsiveness. A study in healthy volunteers. Arzneimittelforschung. 1987 Feb;37(2):214-7.

Density	1.263g/cm3
Boiling Point	561.8ºC at 760 mmHg
Molecular Formula	C₁₉H₁₉NO₆
Molecular Weight	357.35700
Flash Point	293.6ºC
Exact Mass	357.12100
PSA	90.93000
LogP	2.87910
Index of Refraction	1.582
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG0929000

CHEMICAL NAME :: Benzoic acid, 2-(acetyloxy)-, 2-(4-(acetylamino)phenoxy)ethyl ester

CAS REGISTRY NUMBER :: 62992-61-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H19-N-O6

MOLECULAR WEIGHT :: 357.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4014921

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AFTOD7 Archivos de Farmacologia y Toxicologia. (Universidad Complutense, Facultad de Medicina, Departamento Coordinado de Farmacologia, Ciudad Universitaria, Madrid 3, Spain) V.1- 1975- Volume(issue)/page/year: 4,167,1978

HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%