VEGFR-2-IN-29

Names

[ CAS No. ]:
62802-77-1

[ Name ]:
VEGFR-2-IN-29

[Synonym ]:
3-Nitro-N-(8-chinolinyl)benzamid
3-Nitro-N-quinolin-8-yl-benzamide

Biological Activity

[Description]:

VEGFR-2-IN-29 (Compound 5) is a VEGFR-2 inhibitor with an IC50 of 16.5 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGFR-2:16.5 nM (IC50)

[In Vitro]

VEGFR-2-IN-29 (Compound 5) (72 h) inhibits HUVEC proliferation[1]. Cell Proliferation Assay[1] Cell Line: HUVEC Concentration: Incubation Time: 72 h Result: Showed inhibition with IC50s of 15.8 nM and 210 nM against VEGF- and bFGF-induced HUVEC proliferation.

[References]

[1]. Yang Y, et al. Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6653-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₁N₃O₃

[ Molecular Weight ]:
293.27700

[ Exact Mass ]:
293.08000

[ PSA ]:
91.30000

[ LogP ]:
4.30250

Synthetic Route

Click to get detail synthetic route

Related Compounds

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