SB 772077B dihydrochloride

Names

[ Name ]:
SB 772077B dihydrochloride

[Synonym ]:
7,8-Dihydroxyflavone

Biological Activity

[Description]:

SB-772077B dihydrochloride is an aminofurazan-based Rho kinase( ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK

Signaling Pathways >> Stem Cell/Wnt >> ROCK

Signaling Pathways >> TGF-beta/Smad >> ROCK

[Target]

ROCK1:5.6 nM (IC50)

ROCK2:6 nM (IC50)

[References]

[1]. Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₀Cl₂N₈O₂

[ Molecular Weight ]:
415.28

[ Exact Mass ]:
414.10900

[ PSA ]:
141.98000

[ LogP ]:
3.08000

SB 772077B dihydrochloride

Names

Biological Activity

Chemical & Physical Properties

Related Compounds