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N-Acetyl-L-cysteine ethyl ester

Names

[ CAS No. ]:
59587-09-6

[ Name ]:
N-Acetyl-L-cysteine ethyl ester

[Synonym ]:
L-2-Acetamino-3-mercapto-propionsaeure-aethylester
N-Acetylcysteine ethylester
N-acetyl-L-cysteine ethyl ester
L-Cysteine,N-acetyl-,ethyl ester
N-Acetyl-L-cystein-aethylester

Biological Activity

[Description]:

N-Acetyl-L-cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

N-Acetyl-L-cysteine ethyl ester is a an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant[1].

[References]

[1]. Daniela Giustarini, et al. N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential. Biochem Pharmacol. 2012 Dec 1;84(11):1522-33.

Chemical & Physical Properties

[ Density]:
1.138g/cm3

[ Boiling Point ]:
337.6ºC at 760 mmHg

[ Molecular Formula ]:
C7H13NO3S

[ Molecular Weight ]:
191.25

[ Flash Point ]:
158ºC

[ Exact Mass ]:
191.06200

[ PSA ]:
97.69000

[ LogP ]:
0.82430

[ Index of Refraction ]:
1.48

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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