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[Tyr11]-Somatostatin

Names

[ CAS No. ]:
59481-27-5

[ Name ]:
[Tyr11]-Somatostatin

[Synonym ]:
Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Tyr-Thr-Ser-Cys
L-Alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-25,28-dibenzyl-4-carboxy-13-(4-hydroxybenzyl)-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide
Glycinamide, L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-13-[(4-hydroxyphenyl)methyl]-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-25,28-bis(phenylmethyl)-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacont-37-yl]-
(Tyr11)-Somatostatin-14

Biological Activity

[Description]:

[Tyr11]-Somatostatin is a neuroavtive peptide for proteomics research. Somatostatin is one of many neuroactive substances that influence retinal physiology[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

Iodination of [Tyr11]-Somatostatin yields a super high affinity ligand for somatostatin receptors in GH4C1 pituitary cells[2].

[References]

[1]. Vasilaki A, et al. Somatostatin mediates nitric oxide production by activating sst(2) receptors in the rat retina. Neuropharmacology. 2002;43(5):899-909.

[2]. Presky DH, Schonbrunn A. Iodination of [Tyr11]somatostatin yields a super high affinity ligand for somatostatin receptors in GH4C1 pituitary cells. Mol Pharmacol. 1988;34(5):651-658.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
2000.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C76H104N18O20S2

[ Molecular Weight ]:
1653.878

[ Flash Point ]:
1163.7±34.3 °C

[ Exact Mass ]:
1652.711548

[ PSA ]:
684.06000

[ LogP ]:
-4.99

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.676

Related Compounds