[Tyr1]-Somatostatin-14

Names

[ Name ]:
[Tyr1]-Somatostatin-14

[Synonym ]:
tyr-gly-cys-lys-asn-phe-phe-trp-lys-thr-phe-thr-ser-cys
(TYR1)-SOMATOSTATIN-14
TYR-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS: YGCKNFFWKTFTSC DISULFIDE BRIDGE CYS3-CYS14
TYR-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS(DISULFIDE BRIDGE: CYS3-CYS14)
1-L-Tyrosinesomatostatin (sheep)
YGCKNFFWKTFTSC(Disulfidebridge:3-14)

Biological Activity

[Description]:

[Tyr1]-Somatostatin-14 could binds to SSTR2[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

Research Areas >> Endocrinology

[References]

[1]. S Kagimoto, et al. Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein. Biochem Biophys Res Commun. 1994 Jul 29;202(2):1188-95.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₂H₁₀₈N₁₈O₂₀S₂

[ Molecular Weight ]:
1729.97000

[ Exact Mass ]:
1728.74000

[ PSA ]:
684.06000

[ LogP ]:
3.21460

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice.

J. Neuroendocrinol. 27 , 872-86, (2015)

Ghrelin, a gut hormone originating from the post-translational cleavage of preproghrelin, is the endogenous ligand of growth hormone secretagogue receptor 1a (GHS-R1a). Within the growth hormone (GH) ...

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.

Sci. Signal. 8 , ra113, (2015)

Skeletal muscle is the largest organ, comprising 40% of the total body lean mass, and affects whole-body metabolism in multiple ways. We investigated the signaling pathways involved in this process us...

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid.

EMBO J. 34 , 1875-88, (2015)

MT1-MMP (MMP14) is a collagenolytic enzyme located at the cell surface and implicated in extracellular matrix (ECM) remodeling. Mmp14(-/-) mice present dwarfism, bone abnormalities, and premature deat...