Di(N-succinimidyl)adipate

Names

[ Name ]:
Di(N-succinimidyl)adipate

[Synonym ]:
adipic acid di-N-hydroxysuccinimide ester
di-(N-hydroxysuccinimidyl) adipate ester
bis(N-hydroxysuccinimidyl) adipate
disuccinimidyl adipate
bis(N-hydroxysuccinimidyl) adipic acid diester
Di(N-succinimidyl) adipate
adipic acid bis(succinimidyl) ester
2,5-Pyrrolidinedione,1,1'-[(1,6-dioxo-1,6-hexanediyl)bis(oxy)]bis

Biological Activity

[Description]:

Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₆N₂O₈

[ Molecular Weight ]:
340.28500

[ Exact Mass ]:
340.09100

[ PSA ]:
127.36000

Di(N-succinimidyl)adipate

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds