3-METHYLGLUTACONIC ACID

Names

[ Name ]:
3-METHYLGLUTACONIC ACID

[Synonym ]:
3-methyl-pentenedioic acid
3-METHYL-2-PENTENEDIOIC ACID
glutacouic acide 3-methyl
3-methylglutaric acid
3-Methylglutaconsaeure
3-METHYL-PENT-2-ENEDIOIC ACID
3-Methyl-pentendisaeure

Biological Activity

[Description]:

3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Guilhian Leipnitz, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62.

[2]. N L Alsip, et al. Cardiovascular effects of 3-mercaptopropionic acid and levels of GABA in regions of the brain of guinea-pigs. Neuropharmacology. 1984 Mar;23(3):349-57.

[3]. E Girardi, et al. 3-mercaptopropionic acid-induced seizures decrease NR2B expression in Purkinje cells: cyclopentyladenosine effect. Cell Mol Neurobiol. 2010 Oct;30(7):985-90.

[4]. Leipnitz G, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62.

Chemical & Physical Properties

[ Density]:
1.307g/cm3

[ Boiling Point ]:
399.4ºC at 760mmHg

[ Melting Point ]:
101 - 105°C (lit.)

[ Molecular Formula ]:
C₆H₈O₄

[ Molecular Weight ]:
144.13

[ Flash Point ]:
209.5ºC

[ Exact Mass ]:
144.04200

[ PSA ]:
74.60000

[ LogP ]:
0.49200

[ Index of Refraction ]:
1.508

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Related Compounds

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