4-Tolylboronic acid

Names

[ Name ]:
4-Tolylboronic acid

[Synonym ]:
(R)-N-methyl-1-phenylethanamine
(4-Methylphenyl)boronic acid
((1R)-1-phenylethyl)methylamine
Boronic acid, B-(4-methylphenyl)-
Benzenemethanamine, N,α-dimethyl-, (αR)-
4-Tolylboronic acid
MFCD00039138
4-Methylphenylboronic acid
(1R)-N-Methyl-1-phenylethanamine
(R)-N-Methyl-α-phenylethylamine
EINECS 202-766-3

Biological Activity

[Description]:

4-Tolueneboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
275.2±33.0 °C at 760 mmHg

[ Melting Point ]:
256-263 °C(lit.)

[ Molecular Formula ]:
C₇H₉BO₂

[ Molecular Weight ]:
135.956

[ Flash Point ]:
120.2±25.4 °C

[ Exact Mass ]:
136.069565

[ PSA ]:
12.03000

[ LogP ]:
2.05

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.528

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XS7400000

CHEMICAL NAME :: p-Tolueneboronic acid

CAS REGISTRY NUMBER :: 5720-05-8

BEILSTEIN REFERENCE NO. :: 2935970

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H9-B-O2

MOLECULAR WEIGHT :: 135.97

WISWESSER LINE NOTATION :: QBQR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 172 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90. Volume(issue)/page/year: 12,173,1961

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
XS7400000

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Articles

Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.

Bioorg. Med. Chem. Lett. 19 , 2642-5, (2009)

Inhibition of the beta-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic fungi Cryptococcus neoformans (Can2) and Candida albicans (Nce103) with a series of aromatic, arylalkenyl- and arylalky...

Direct palladium(II)-catalyzed synthesis of arylamidines from aryltrifluoroborates.

Org. Lett. 9th ed., 14 , 2394-2397, (2012)

A fast and convenient synthesis of arylamidines starting from readily available potassium aryltrifluoroborates and cyanamides is reported. The coupling was achieved by Pd(II)-catalysis in a one step 2...

Ruthenium(0)-catalyzed sp3 C-H bond arylation of benzylic amines using arylboronates.

Org. Lett. 7th ed., 14 , 1930-1933, (2012)

A Ru-catalyzed direct arylation of benzylic sp(3) carbons of acyclic amines with arylboronates is reported. This highly regioselective and efficient transformation can be performed with various combin...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.