Nepitrin

Names

[ CAS No. ]:
569-90-4

[ Name ]:
Nepitrin

[Synonym ]:
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(β-D-glucopyranosyloxy)-5-hydroxy-6-methoxy-
nepitrin
6-Methoxyluteolin 7-glucoside
2-(3,4-Dihydroxyphenyl)-5-hydroxy-6-methoxy-4-oxo-4H-chromen-7-yl β-D-glucopyranoside
6-Methoxyluteolin 7-O-glucoside

Biological Activity

[Description]:

Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Monsef-Esfahani HR, et al. Flavonoids, cinnamic acid and phenyl propanoid from aerial parts of Scrophularia striata. Pharm Biol. 2010 Mar;48(3):333-6.

[2]. Agarwal OP, et al. The anti-inflammatory action of nepitrin, a flavonoid. Agents Actions. 1982 Jul;12(3):298-302.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
844.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₂O₁₂

[ Molecular Weight ]:
478.403

[ Flash Point ]:
294.9±27.8 °C

[ Exact Mass ]:
478.111115

[ PSA ]:
199.51000

[ LogP ]:
-0.68

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.715

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3009500

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)- 5-hydroxy-6- methoxy-

CAS REGISTRY NUMBER :: 569-90-4

LAST UPDATED :: 199403

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H22-O12

MOLECULAR WEIGHT :: 478.44

WISWESSER LINE NOTATION :: T66 BO EVJ CR CQ DQ& GQ HO1 IO- BT6OTJ CQ DQ EQ F1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 794 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 19,201,1981

Precursor & DownStream

Precursor

DownStream

Related Compounds

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