Imidocarb dipropionate

Names

[ Name ]:
Imidocarb dipropionate

[Synonym ]:
MFCD00013161
Imizol
Imidocarb Dipropionate
Propanoic acid - 1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea (2:1)
Propanoic acid, compd. with urea, N,N'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]- (2:1)
EINECS 259-791-8

Biological Activity

[Description]:

Imidocarb dipropionate is a potent antiprotozoal agent. Imidocarb dipropionate is active against the parasite B. bovis with an IC50 of 87 μg/mL[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: 87 μg/mL (Parasite B. bovis)[1]

[In Vivo]

Imidocarb dipropionate is administered by subcutaneous or intramuscular injection to horses (3.4 mg/kg bw) and cattle (2.I mg/kg bw). In horses, up to 4 doses may be given at 72-hour intervals. A second dose may be given 2 weeks after the first[1]. Imidocarb dipropionate is also used in sheep (1. 2mg/kg bw) for the treatment of babesiosis and anaplasmosis[1]. The acute oral LD50 value of Imidocarb dipropionate is in the range of 646 to 723 mg/kg bw in mice[1]. The acute oral LD50 value of Imidocarb is in the range of 454 to 1251 mg/kg bw in rats[1].

[References]

[1]. Rodriguez RI, et al. In vitro responsiveness of Babesia bovis to Imidocarb dipropionate and the selection of a drug-adapted line. Vet Parasitol. 1996 Mar;62(1-2):35-41.

Chemical & Physical Properties

[ Density]:
1.39g/cm3

[ Melting Point ]:
205ºC

[ Molecular Formula ]:
C₂₅H₃₂N₆O₅

[ Molecular Weight ]:
496.559

[ Exact Mass ]:
496.243408

[ PSA ]:
164.51000

[ LogP ]:
2.66700

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Comparison of glycopyrrolate and atropine in ameliorating the adverse effects of imidocarb dipropionate in horses.

Equine Vet. J. 45(5) , 625-9, (2013)

Imidocarb, an effective treatment for piroplasmosis, may cause colic and diarrhoea in horses. Atropine and glycopyrrolate are anticholinergics that could reduce the adverse effects of imidocarb. Howev...

Failure of combination therapy with imidocarb dipropionate and toltrazuril to clear Hepatozoon canis infection in dogs.

Parasitol. Res. 109(3) , 919-26, (2011)

Current treatments with imidocarb dipropionate for infected dogs with Hepatozoon canis do not always provide parasitological cure. The objective of this study is to determine whether concomitant use o...

Alterations in some blood coagulation parameters in naturally occurring cases of canine babesiosis.

Acta Vet. Hung. 57(2) , 295-304, (2009)

Changes in coagulation parameters were studied in dogs naturally infected with Babesia canis canis (n = 30), and haemostasis was evaluated and compared to values obtained from healthy dogs (n = 29). T...