<Suppliers Price>

BECLOMETASONE DIPROPIONATE MONOHYDRATE

Names

[ CAS No. ]:
77011-63-3

[ Name ]:
BECLOMETASONE DIPROPIONATE MONOHYDRATE

[Synonym ]:
4H7L9AI22I
beclomethasone dipropionate monohydrate
UNII-4H7L9AI22I

Biological Activity

[Description]:

Beclometasone dipropionate monohydrate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma [1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[In Vitro]

Beclometasone dipropionate monohydrate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells[2]. Western Blot Analysis[2] Cell Line: 16HBE cells Concentration: 1, 10 and 100 nM Incubation Time: 20 min Result: Reduced the levels of iNOS, ROS and NT generated by rhIL-17A.

[In Vivo]

Beclometasone dipropionate monohydrate (150 µg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number[1]. Animal Model: Male BALB/c mice with asthma[1] Dosage: 150 µg/kg Administration: Nebulization Result: Decreased total cell number and relative eosinophil number in BALF.

[References]

[1]. Hrvacić B, et, al. Applicability of an ultrasonic nebulization system for the airways delivery of beclomethasone dipropionate in a murine model of asthma. Pharm Res. 2006 Aug;23(8):1765-75.

[2]. Montalbano AM, et, al. Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells. Eur J Pharmacol. 2013 Oct 15;718(1-3):418-27.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H51ClO12

[ Molecular Weight ]:
687.21500

[ Exact Mass ]:
686.30700

[ PSA ]:
190.80000

[ LogP ]:
4.98450

Related Compounds