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Soyasaponin II

Names

[ CAS No. ]:
55319-36-3

[ Name ]:
Soyasaponin II

[Synonym ]:
MFCD04039836

Biological Activity

[Description]:

Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Signaling Pathways >> Anti-infection >> HSV
Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> CMV

[Target]

HSV-1:54 μM (IC50)

HIV-1:112 μM (IC50)

influenza virus:88 μM (IC50)

HCMV:104 μM (IC50)

NLRP3 inflammasome


[In Vitro]

Soyasaponin II inhibits the replication of HSV-1 (IC50=54μM), HCMV (104μM), influenza virus (88μM), and HIV-1 (112 μM)[1].

[In Vivo]

Soyasaponin II (5 mg/kg; p.o.; once a day for three consecutive days) ameliorates canonical NLRP3 inflammasome-associated innate immune response[2].

[References]

[1]. Hayashi K, et al. Inhibitory activity of soyasaponin II on virus replication in vitro. Planta Med. 1997;63(2):102-105.

[2]. Wang F, et al. Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice. Theranostics. 2020;10(6):2714-2726. Published 2020 Feb 3.

Chemical & Physical Properties

[ Molecular Formula ]:
C47H76O17

[ Molecular Weight ]:
913.09600

[ Exact Mass ]:
912.50800

[ PSA ]:
274.75000

[ LogP ]:
1.34370

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds