3,3'',5-Triiodo-L-thyronine Sodium Salt

Names

[ CAS No. ]:
55-06-1

[ Name ]:
3,3'',5-Triiodo-L-thyronine Sodium Salt

[Synonym ]:
Liothyronine (sodium)
Cytobin
Liothyronine sodium salt
Ibiot
Basoprocin
Sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
UNII:GCA9VV7D2N
Sodium 3,3',5-triiodo-L-thyronine
Sodium T3
T3,NA
EINECS 200-223-5
sodium (S)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoate
Liothyronine sodium
Cynomel
sodium triiodothyronine
Cytomine
Triothyrone
Cyomel
L-3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]alanine Monosodium Salt
T3 sodium salt
Triostat
3,3',5-Triiodo-L-thyronine sodium salt
Tertroxin
tri-iodothyronine sodium
L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, sodium salt (1:1)
Sodium L-Triiodothyronine
MFCD00002594
T3
3,3',5-Triiodo-L-thyronine (sodium)

Biological Activity

[Description]:

3,3',5-Triiodo-L-thyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.

[Related Catalog]:

Signaling Pathways >> Others >> Thyroid Hormone Receptor

Research Areas >> Cancer

Research Areas >> Endocrinology

[Target]

TRβ1[1][2]

[In Vitro]

3,3',5-Triiodo-L-thyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. 3,3',5-Triiodo-L-thyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. 3,3',5-Triiodo-L-thyronine promotes growth, induces differentiation and regualtes metabolic effects[2].

[Cell Assay]

Thyroid hormone depleted (Td) serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of 3,3',5-Triiodo-L-thyronine (T3) on the growth of cells, cells are plated at a density of 3 × 104 cells/60 mm dish on day 0, and incubated in medium containing 5% regular serum, 5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1].

[References]

[1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.

[2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
563.5ºC at 760 mmHg

[ Melting Point ]:
205 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₅H₁₁I₃NNaO₄

[ Molecular Weight ]:
672.955

[ Flash Point ]:
294.6ºC

[ Exact Mass ]:
672.771973

[ PSA ]:
95.61000

[ LogP ]:
3.31830

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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