IHR 1

Names

[ Name ]:
IHR 1

[Synonym ]:
IHR-1
N,N'-1,4-Phenylenebis(2,5-dichlorobenzamide)
MFCD03404776
Benzamide, N,N'-1,4-phenylenebis[2,5-dichloro-
N,N'-1,4-Phenylenebis[2,5-dichloro-benzamide]

Biological Activity

[Description]:

A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response.

[References]

References 1. Fan CW, et al. Chem Biol. 2014 Dec 18;21(12):1680-9. View Related Products by Target Smoothened (Smo)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
488.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₂Cl₄N₂O₂

[ Molecular Weight ]:
454.134

[ Flash Point ]:
249.2±28.7 °C

[ Exact Mass ]:
451.965302

[ LogP ]:
5.01

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.708

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Statements ]:
H413

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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