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2-Keto-D-galactose

Names

[ CAS No. ]:
54142-77-7

[ Name ]:
2-Keto-D-galactose

[Synonym ]:
D-arabino-hexos-2-ulose
D-arabino-hexosulose
D-glucosone
arabino-hexos-2-ulose
3-deoxyglucosone
2-keto-D-glucose
galactosone

Biological Activity

[Description]:

2-Keto-D-galactose (D-Galactosone) inhibits DNA synthesis, and inhibits proliferation of in vitro grown Ehrlich ascites tumor cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

DNA synthesis[1]


[In Vitro]

2 mM 2-Keto-D-galactose (Galactosone) causes a comparable inhibition of DNA synthesis. Proliferation of in vitro grown Ehrlich ascites tumor cells is completely inhibited by 1-2 mM 2-Keto-D-galactose without severely affecting viability (dye exclusion test); no phase-specific arrest of cell growth is observed[1].

[References]

[1]. Reiffen KA, et al. A comparative study on proliferation, macromolecular synthesis and energy metabolism of in vitro-grown Ehrlich ascites tumor cells in the presence of glucosone, galactosone and methylglyoxal. J Cancer Res Clin Oncol. 1984;107(3):206-10.

Chemical & Physical Properties

[ Density]:
1.574g/cm3

[ Boiling Point ]:
481ºC at 760mmHg

[ Molecular Formula ]:
C6H10O6

[ Molecular Weight ]:
178.14000

[ Flash Point ]:
258.8ºC

[ Exact Mass ]:
178.04800

[ PSA ]:
115.06000

[ Index of Refraction ]:
1.55

Related Compounds