medroxyprogesterone
Names
[ CAS No. ]:
520-85-4
[ Name ]:
medroxyprogesterone
[Synonym ]:
Medroxyprogesteron
Medroxyprogesteronum
Hydroxymethylprogesterone
MFCD00069474
17α-Hydroxy-6α-methylprogesterone
Medroxy Progesterone
17-Hydroxy-6α-methylprogesterone
Medrossiprogesterone
17alpha-Hydroxy-6alpha-methylprogesterone
(6a)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione
17-Hydroxy-6a-methylprogesterone
Medroxiprogesterone
17a-Hydroxy-6a-methylprogesterone
17-Hydroxy-6alpha-methylprogesterone
6a-Methyl-17a-hydroxyprogesterone
6α-Methyl-17α-hydroxyprogesterone
Farlutal
17α-Hydroxy-6α-methylpregn-4-ene-3,20-dione
EINECS 208-298-6
(6α)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione
Pregn-4-ene-3,20-dione, 17-hydroxy-6α-methyl-
medroxyprogesterone
(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Pregn-4-ene-3,20-dione, 17-hydroxy-6-methyl-, (6α)-
Medroxiprogesteronum
Pregn-4-ene-3,20-dione, 17α-hydroxy-6α-methyl-
Medroxyprogesterone Base
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
488.0±45.0 °C at 760 mmHg
[ Melting Point ]:
220-223.5ºC
[ Molecular Formula ]:
C22H32O3
[ Molecular Weight ]:
344.488
[ Flash Point ]:
263.0±25.2 °C
[ Exact Mass ]:
344.235138
[ PSA ]:
54.37000
[ LogP ]:
3.38
[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C
[ Index of Refraction ]:
1.554
[ Storage condition ]:
Refrigerator
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU5300000
- CHEMICAL NAME :
- Pregn-4-ene-3,20-dione, 17-hydroxy-6-alpha-methyl-
- CAS REGISTRY NUMBER :
- 520-85-4
- BEILSTEIN REFERENCE NO. :
- 2510965
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C22-H32-O3
- MOLECULAR WEIGHT :
- 344.54
- WISWESSER LINE NOTATION :
- L E5 B666 OV MUTJ A1 E1 FV1 FQ K1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 6 mg/kg/13W-I
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914- Volume(issue)/page/year: 163,51,1995 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 17-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 24,77,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 625 mg/kg
- SEX/DURATION :
- female 10 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,445,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1120 mg/kg
- SEX/DURATION :
- male 16 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- REFERENCE :
- ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 187,431,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 5 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- 85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,57,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7306 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 339 (estimated) No. of Female Employees: 170 (estimated)
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H361
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
48-63-68
[ Safety Phrases ]:
22-24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
TU5300000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
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