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Megestrol

Names

[ CAS No. ]:
3562-63-8

[ Name ]:
Megestrol

[Synonym ]:
MFCD01939877
EINECS 222-628-6
17-Hydroxy-6-methyl-pregna-4,6-dien-3,20-dion
17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE
Megestrol
Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
20-dione,17-hydroxy-6-methyl-pregna-6-diene-3

Biological Activity

[Description]:

Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1].

[References]

[1]. Garcia JM, et al. Off-Label Megestrol in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2018 Jun;131(6):623-629.e1.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
500.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H30O3

[ Molecular Weight ]:
342.472

[ Flash Point ]:
270.5±26.6 °C

[ Exact Mass ]:
342.219482

[ PSA ]:
54.37000

[ LogP ]:
3.06

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.569

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4074500
CHEMICAL NAME :
Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
CAS REGISTRY NUMBER :
3562-63-8
LAST UPDATED :
199606
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H20-O3
MOLECULAR WEIGHT :
332.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/kg/15D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 11(3),17,1991

Precursor & DownStream

Precursor

DownStream

Related Compounds