MTOB

Names

[ Name ]:
MTOB

[Synonym ]:
KMBA
MFCD00010511
sodium 4-methylsulfanyl-2-oxo-butyrate
UNII-2EZY36W75U
Sodium 4-(methylthio)-2-oxobutanoate
sodium 4-methylthio-2-oxobutyrate
Fema No. 3881
4-Methylthio-2-oxobutanoic acid sodium salt

Biological Activity

[Description]:

MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell lines[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[Target]

CtBP[1]

[In Vitro]

MTOB sodium (10 mM) causes significant derepression (P<0.05) of 40% of CtBP target genes (including FGF9, CTNNB1, CEBPB, et al.) in MCF-7 and 46% in MBA-MD-231; increases the pro-epithelial E-cadherin/Vimentin ratio while reducing the pro-mesenchymal CD44/CD24 ratio, with a more significant trend (P<0.05) in MCF-7[2].

[In Vivo]

MTOB sodium (860 mg/kg; IP, at 1 h and 18 h after the first injury) effectively suppresses the increases duration of righting reflex, and significantly decreased neurological severity score (NSS) scores[1]. Animal Model: C57BL/6 mice (traumatic brain injury)[1] Dosage: 860 mg/kg Administration: IP, at 1 h and 18 h after the first injury Result: Effectively suppressed the increased duration of righting reflex, and significantly decreased NSS scores.

[References]

[1]. Li H, et al. C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment. Int J Biol Sci. 2020 Feb 4;16(7):1107-1120.

[2]. Di LJ, et al. Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nat Commun. 2013;4:1449.

Chemical & Physical Properties

[ Melting Point ]:
>300ºC(lit.)

[ Molecular Formula ]:
C₅H₇NaO₃S

[ Molecular Weight ]:
170.16200

[ Exact Mass ]:
170.00100

[ PSA ]:
82.50000

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
UN 3335

[ HS Code ]:
2930909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

[Effect of substrate-dependent microbialy produced ethylene on plant growth].

Mikrobiologiia 75(2) , 277-83, (2006)

Various compounds have been identified as precursors/substrates for the synthesis of ethylene (C2H4) in soil. This study was designed to compare the efficiency of four substrates, namely L-methionine ...

Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1.

Nat. Chem. Biol. 9(4) , 244-6, (2013)

We identify an Arabidopsis pyridoxal-phosphate-dependent aminotransferase, VAS1, whose loss-of-function simultaneously increases amounts of the phytohormone auxin and the ethylene precursor 1-aminocyc...

Significant enhancement of methionol production by co-expression of the aminotransferase gene ARO8 and the decarboxylase gene ARO10 in Saccharomyces cerevisiae.

FEMS Microbiol. Lett. 362 , (2015)

Methionol is an important volatile sulfur flavor compound, which can be produced via the Ehrlich pathway in Saccharomyces cerevisiae. Aminotransferase and decarboxylase are essential enzymes catalyzin...