N-Boc-1,5-diaminopentane

Names

[ Name ]:
N-Boc-1,5-diaminopentane

[Synonym ]:
N-Boc-cadaverine
N-(5-Aminopentyl)carbamic Acid tert-Butyl Ester
tert-Butyl (5-aminopentyl)carbamate
N-(tert-Butoxycarbonyl)-1,5-pentanediamine
N-Boc-1,5-diaminopentane
tert-butyl N-(5-aminopentyl)carbamate
N-Boc-1,5-pentanediamine
2-Methyl-2-propanyl (5-aminopentyl)carbamate
Carbamic acid, N-(5-aminopentyl)-, 1,1-dimethylethyl ester
N-(5-Aminoamyl)carbamic Acid tert-Butyl Ester
MFCD00210020
N-(tert-Butoxycarbonyl)-1,5-diaminopentane

Biological Activity

[Description]:

PROTAC Linker 23 is a PROTAC linker, which refers to the alkyl chain composition. PROTAC Linker 23 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
309.2±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₂₂N₂O₂

[ Molecular Weight ]:
202.294

[ Flash Point ]:
140.8±23.2 °C

[ Exact Mass ]:
202.168121

[ PSA ]:
64.35000

[ LogP ]:
1.29

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.458

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 3

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Structure-activity relationships among methoctramine-related polymethylene tetraamines. Chain-length and substituent effects on M-2 muscarinic receptor blocking activity.

J. Med. Chem. 32 , 79, (1989)

Several polymethylene tetraamines related to methoctramine (1) were prepared and evaluated for their blocking activity on M-2 muscarinic receptors in guinea pig atria and ileum. It turned out that ant...

T. Teshima et al.

Tetrahedron 47 , 3305, (1991)

V.J. Jasys et al.

J. Org. Chem. 57 , 1814, (1992)