Esflurbiprofen

Names

[ Name ]:
Esflurbiprofen

[Synonym ]:
[1,1'-biphenyl]-4-acetic acid, 2-fluoro-a-methyl-
2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic acid
2-FLUORO-α-METHYL-4-BIPHENYLACETIC ACID
2-(2-Fluoro-4-biphenylyl)propanoic acid
Froben
Anside
EINECS 257-263-1
d-Flurbiprofen
[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-
Stayban
Esflurbiprofen
MFCD00866152
(S)-Flurbiprofen
2-(2-fluorobiphenyl-4-yl)propanoic acid
Ocufen
Ansaid
(±)-Flurbiprofen
2-(2-fluoro-4-biphenylyl)propionic acid
Zepolas
Adfeed
rac-Flurbiprofen
tarenflurbil
Flurbiprofen

Biological Activity

[Description]:

(S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

Signaling Pathways >> Immunology/Inflammation >> PGE synthase

[Target]

COX-1:0.48 μM (IC50)

COX-2:0.47 μM (IC50)

[In Vitro]

(S)-Flurbiprofen (10–7 M) results in a total suppression of basal and stimulated PGE2 release in rat skin[2].

[References]

[1]. A Carabaza, et al. Stereoselective Inhibition of Inducible Cyclooxygenase by Chiral Nonsteroidal Antiinflammatory Drugs. J Clin Pharmacol. 1996 Jun;36(6):505-12.

[2]. B Averbeck, et al. Inflammatory Mediators Do Not Stimulate CGRP Release if Prostaglandin Synthesis Is Blocked by S(+)-flurbiprofen in Isolated Rat Skin. Inflamm Res. 2003 Dec;52(12):519-23.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
376.2±30.0 °C at 760 mmHg

[ Melting Point ]:
109-110ºC(lit.)

[ Molecular Formula ]:
C₁₅H₁₃FO₂

[ Molecular Weight ]:
244.261

[ Flash Point ]:
181.3±24.6 °C

[ Exact Mass ]:
244.089951

[ PSA ]:
37.30000

[ LogP ]:
4.11

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.568

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
36/37/39-45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3