Indican

Names

[ CAS No. ]:
487-60-5

[ Name ]:
Indican

[Synonym ]:
Indikan
Plant indican
Indican
Indole, 3- (β-D-glucopyranosyloxy)-
3-Indolyl-b-D-glucopyranoside
3-Indole-D-glucoside Hydrate
Indoxyl-D-glucoside Hydrate
Indoxyl β-D-glucoside
1H-Indol-3-yl β-D-glucopyranoside
1H-Indol-3-yl β-glucopyranoside
Indoxyl-b-D-glucoside
3-Indolyl-D-glucoside Hydrate
Indoxyl-β-D-glucoside
Indican Hydrate
Uroxanthin
3-Indoxyl-beta-D-glucopyranoside
3-Indoxyl-D-glucoside Hydrate
3-(b-Glucosido)indole
1H-Indol-3-yl-b-D-glucopyranoside
MFCD00047169
Indole, 3-(β-D-glucopyranosyloxy)-
3-Indoxyl-β-D-glucopyranoside
β-D-Glucopyranoside, 1H-indol-3-yl

Biological Activity

[Description]:

Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vivo]

Indican ((Indoxyl-β-D-glucoside; oral; 20, 40 mg/kg; single dose) increases the systemic exposure and MRT of MTX through inhibition on multiple anion transporters including OAT 1, OAT 3 and MRP 4 by the major metabolite IS[1]. Animal Model: Male Spraguee Dawley rats weighing 330-400 g[1] Dosage: 20, 40 mg/kg Administration: Orally Result: Increased the systemic exposure and multidrug resistance-associated protein (MRP) of Methotrexate (MTX; 5.0 mg/kg).

[References]

[1]. Shiuan-Pey Lin, et al. Transporter-mediated interaction of indican and methotrexate in rats. J Food Drug Anal. 2018 Apr;26(2S):S133-S140.

[2]. Yu-Chi Hou, et al. Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats. Toxicon. 2008 Sep 1;52(3):440-4.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
606.7±55.0 °C at 760 mmHg

[ Melting Point ]:
57-58ºC

[ Molecular Formula ]:
C₁₄H₁₇NO₆

[ Molecular Weight ]:
295.288

[ Flash Point ]:
320.7±31.5 °C

[ Exact Mass ]:
295.105591

[ PSA ]:
115.17000

[ LogP ]:
-0.75

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.715

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 0.1 M at 20 °C, clear to slightly hazy, colorless to faint yellow-green

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A modified m-CP medium for enumerating Clostridium perfringens from water samples.

Can. J. Microbiol. 34 , 78, (1988)

Medium m-CP, designed for the isolation of Clostridium perfringens from water samples, contains indoxyl beta-D-glucoside, an expensive chemical that is present at a high concentration in this medium. ...

[Determination of indican in Polygonum tinctorium ait. in various growth periods].

Zhong Yao Tong Bao 13(11) , 11-3, 61-2, (1988)

Distribution, diversity, and seasonality of waterborne salmonellae in a rural watershed.

Appl. Environ. Microbiol. 75(5) , 1248-55, (2009)

Salmonella outbreaks from contaminated water and nonanimal foods (e.g., produce) are increasingly reported. To address the environment as a potential source of pathogenic Salmonella, we investigated l...

Related Compounds

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