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CP-339818 hydrochloride

Names

[ CAS No. ]:
478341-55-8

[ Name ]:
CP-339818 hydrochloride

[Synonym ]:
(4E)-1-Benzyl-N-pentyl-4(1H)-quinolinimine hydrochloride (1:1)
1-Pentanamine, N-[(4E)-1-(phenylmethyl)-4(1H)-quinolinylidene]-, hydrochloride (1:1)
MFCD19053250
CP-339818
N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride
MFCD09878238

Biological Activity

[Description]:

CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM; displays selectivity over Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2, with only exception Kv1.4 (IC50=300 nM), also has no effect on T cell channels (I(CRAC) and intermediate-conductance K(Ca)); inhibits Kv1.3 in a use-dependent manner by preferentially blocking the C-type inactivated state of the channel; suppresses human T cell activation.

[References]

References 1. Nguyen A, et al. Mol Pharmacol. 1996 Dec;50(6):1672-9. 2. Jäger H, et al. J Physiol. 1998 Jan 15;506 ( Pt 2):291-301. 3. Lee YT, et al. Eur J Pharmacol. 2008 Feb 26;581(1-2):97-104. View Related Products by Target Potassium Channel

Chemical & Physical Properties

[ Molecular Formula ]:
C21H25ClN2

[ Molecular Weight ]:
340.890

[ Exact Mass ]:
340.170624

[ Storage condition ]:
2-8℃

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds