Bufa-20,22-dienolide,3,14-dihydroxy-, (3a,5b)-

Names

[ CAS No. ]:
465-20-3

[ Name ]:
Bufa-20,22-dienolide,3,14-dihydroxy-, (3a,5b)-

[Synonym ]:
3-epibufalin

Biological Activity

[Description]:

3-epi-Bufalin (compound 2a) is the microbial transformation product of bufadienolide[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Ma X C, et al. Highly selective isomerization and dehydrogenation of three major bufadienolides at 3-OH by Fusarium solani[J]. Enzyme and microbial technology, 2007, 40(6): 1585-1591.

Chemical & Physical Properties

[ Density]:
1.226g/cm3

[ Boiling Point ]:
556.6ºC at 760mmHg

[ Molecular Formula ]:
C₂₄H₃₄O₄

[ Molecular Weight ]:
386.52400

[ Flash Point ]:
189ºC

[ Exact Mass ]:
386.24600

[ PSA ]:
70.67000

[ LogP ]:
4.24190

[ Vapour Pressure ]:
1.05E-14mmHg at 25°C

[ Index of Refraction ]:
1.593

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EI2962400

CHEMICAL NAME :: 5-beta-Bufa-20,22-dienolide, 3-alpha,14-dihydroxy-

CAS REGISTRY NUMBER :: 465-20-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H34-O4

MOLECULAR WEIGHT :: 386.58

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 IQ OQ F- ET6OVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 970 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,190,1963

Safety Information

[ RIDADR ]:
UN 3172

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Precursor & DownStream

Precursor

DownStream

Related Compounds

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