Bufalin
Names
[ CAS No. ]:
465-21-4
[ Name ]:
Bufalin
[Synonym ]:
3,14-dihydroxybufa-20,22-dienolide
(3β,5β)-3,14-Dihydroxybufa-20,22-dienolide
Bufalin: Bufa-20,22-dienolide, 3,14-dihydroxy-, (3b,5b)-,
Bufa-20,22-dienolide, 3,14-dihydroxy-, (3β,5β)-
5β-Bufa-20,22-dienolide, 3β,14-dihydroxy-
3β,14β-dihydroxy-5β-bufa-20,22-dienolide
(3b,5b)-3,14-Dihydroxybufa-20,22-dienolide
Bufalin
MFCD00056525
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
556.6±50.0 °C at 760 mmHg
[ Melting Point ]:
242 - 243ºC
[ Molecular Formula ]:
C24H34O4
[ Molecular Weight ]:
386.524
[ Flash Point ]:
189.0±23.6 °C
[ Exact Mass ]:
386.245697
[ PSA ]:
70.67000
[ LogP ]:
3.42
[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C
[ Index of Refraction ]:
1.594
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EI2962500
- CHEMICAL NAME :
- 5-beta-Bufa-20,22-dienolide, 3-beta,14-dihydroxy-
- CAS REGISTRY NUMBER :
- 465-21-4
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C24-H34-O4
- MOLECULAR WEIGHT :
- 386.58
- WISWESSER LINE NOTATION :
- L E5 B666TJ A1 E1 IQ OQ F- ET6OVJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 740 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 140 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,189,1963
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 137 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 24,222,1949
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300
[ Precautionary Statements ]:
P264-P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+: Very toxic;
[ Risk Phrases ]:
R28
[ Safety Phrases ]:
28-36/37-45
[ RIDADR ]:
UN 3462
[ WGK Germany ]:
3
[ RTECS ]:
EI2962500
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
Articles
Am. J. Chin. Med. 42(3) , 729-42, (2014)
Bufalin is a key component of a Chinese medicine (Chan Su) and has been proved effective in killing various cancer cells. Its role in inducing DNA damage and the inhibition of the DNA damage response ...
Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.Sci. Rep. 5 , 17047, (2015)
Sodium taurocholate cotransporting polypeptide (NTCP) has been reported as a functional receptor for hepatitis B virus (HBV) infection. However, HBV could not efficiently infect HepG2 cells expressing...
Reversal effect of bufalin on multidrug resistance in K562/VCR vincristine-resistant leukemia cell line.J. Tradit. Chin. Med. 34(6) , 678-83, (2014)
To probe insights into the reversal effect of bufalin on vincristine-acquired multidrug resistance (MDR) in human leukemia cell line K562/VCR.Proliferative inhibition rate and the reversal index (RI) ...