levofenfluramine
Controlled Substances
Names
[ CAS No. ]:
458-24-2
[ Name ]:
levofenfluramine
[Synonym ]:
redux
DEXFENFLURAMINE HCL
l-Fenfluramine
EINECS 207-276-3
(R)-N-Ethyl-a-methyl-3-(trifluoromethyl)benzeneethanamine
Benzeneethanamine, N-ethyl-α-methyl-3-(trifluoromethyl)-, (αR)-
(aR)-N-Eethyl-a-methyl-3-(trifluoromethyl)benzeneethanamine
(R)-fenfluramine
adifax
levofenfluramine
(R)-(-)-Fenfluramine
DL-Fenfluramine
(2R)-N-Ethyl-1-[3-(trifluoromethyl)phenyl]-2-propanamine
FENFLURAMINE
dextrofenfluramine
(-)-Fenfluramine
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
243.1±35.0 °C at 760 mmHg
[ Melting Point ]:
170°C
[ Molecular Formula ]:
C12H16F3N
[ Molecular Weight ]:
231.257
[ Flash Point ]:
100.8±25.9 °C
[ Exact Mass ]:
231.123489
[ PSA ]:
12.03000
[ LogP ]:
3.05
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.455
[ Storage condition ]:
?20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SH6820000
- CHEMICAL NAME :
- Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-
- CAS REGISTRY NUMBER :
- 458-24-2
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C12-H16-F3-N
- MOLECULAR WEIGHT :
- 231.29
- WISWESSER LINE NOTATION :
- FXFFR C1YM2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Cardiac - other changes
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,1306,1969
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 4286 ug/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - sympathomimetic Behavioral - hallucinations, distorted perceptions
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 34,205,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,177,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 145 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 188,271,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 53 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - rigidity (including catalepsy) Skin and Appendages - hair
- REFERENCE :
- 17XKAB "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970 Volume(issue)/page/year: -,75,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - rigidity (including catalepsy) Skin and Appendages - hair
- REFERENCE :
- 17XKAB "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970 Volume(issue)/page/year: -,75,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - rigidity (including catalepsy) Skin and Appendages - hair
- REFERENCE :
- 17XKAB "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970 Volume(issue)/page/year: -,75,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - rigidity (including catalepsy) Skin and Appendages - hair
- REFERENCE :
- 17XKAB "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970 Volume(issue)/page/year: -,75,1970 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 280 mg/kg
- SEX/DURATION :
- female 7-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 17,39A,1978 *** REVIEWS *** TOXICOLOGY REVIEW PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933- Volume(issue)/page/year: 213,159,1974
Safety Information
[ Hazard Codes ]:
F,T
[ Risk Phrases ]:
11-23/24/25-39/23/24/25
[ Safety Phrases ]:
16-36/37-45