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Enniatin A1

Names

[ CAS No. ]:
4530-21-6

[ Name ]:
Enniatin A1

Biological Activity

[Description]:

Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

ERK


[References]

[1]. Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40.

Chemical & Physical Properties

[ Molecular Formula ]:
C35H61N3O9

[ Molecular Weight ]:
667.87400

[ Exact Mass ]:
667.44100

[ PSA ]:
139.83000

[ LogP ]:
3.74630

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H331

[ Precautionary Statements ]:
P261-P280-P301 + P310-P311

[ RIDADR ]:
UN 3462 6.1 / PGIII

Related Compounds