Enniatin A

Names

[ Name ]:
Enniatin A

[Synonym ]:
ENNIATIN A (LATERITIN I)
ENNIATIN A
Enniatin-A

Biological Activity

[Description]:

Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 22 μM in an enzyme assay using rat liver microsomes[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase

[Target]

ACAT

[In Vitro]

Enniatin A exhibits cytotoxic effects in HeLa cell lines with IC50s of 1.15 μM concentration for 24 h and 0.57 μM concentration for 48 h[2].

[References]

[1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32.

[2]. Mamur S, et al. Assessment of cytotoxic and genotoxic effects of enniatin-A in vitro. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Aug;35(8):1633-1644.

Chemical & Physical Properties

[ Density]:
1.022±0.06 g/cm3

[ Boiling Point ]:
847.4±65.0 °C

[ Melting Point ]:
122-124 °C

[ Molecular Formula ]:
C₃₆H₆₃N₃O₉

[ Molecular Weight ]:
681.90000

[ Exact Mass ]:
681.45600

[ PSA ]:
139.83000

[ LogP ]:
4.13640

[ Vapour Pressure ]:
5.53E-29mmHg at 25°C

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H331

[ Precautionary Statements ]:
P261-P280-P301 + P310-P311

[ Hazard Codes ]:
T

[ Risk Phrases ]:
23/24/25

[ RIDADR ]:
UN 2811

Precursor & DownStream

Precursor

DownStream

Related Compounds

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