2-fluoro-4-methyl-aniline
Names
[ CAS No. ]:
452-80-2
[ Name ]:
2-fluoro-4-methyl-aniline
[Synonym ]:
4-Amino-3-fluorotoluene
Benzenamine, 2-fluoro-4-methyl-
p-Toluidine, 2-fluoro-
2-Fluoro-4-methylaniline
Aniline, 2-fluoro-4-methyl-
2-Fluoro-4-methyaniline
ZR BF D1
MFCD00040975
EINECS 259-564-3
2-Fluoro-4-methylbenzenamine
2-Fluoro-p-toluidine
2-fluoro-4-methyl-aniline
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
196.5±0.0 °C at 760 mmHg
[ Melting Point ]:
3 °C
[ Molecular Formula ]:
C7H8FN
[ Molecular Weight ]:
125.144
[ Flash Point ]:
79.4±0.0 °C
[ Exact Mass ]:
125.064079
[ PSA ]:
26.02000
[ LogP ]:
1.73
[ Vapour Pressure ]:
0.4±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.542
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XU6650000
- CHEMICAL NAME :
- p-Toluidine, 2-fluoro-
- CAS REGISTRY NUMBER :
- 452-80-2
- BEILSTEIN REFERENCE NO. :
- 2637578
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C7-H8-F-N
- MOLECULAR WEIGHT :
- 125.16
- WISWESSER LINE NOTATION :
- ZR BF D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H311-H315-H319-H331-H335
[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic;
[ Risk Phrases ]:
R23/24/25;R36/37/38
[ Safety Phrases ]:
S26-S36/37/39-S45
[ RIDADR ]:
UN 2810 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
XU6650000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2921430090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921430090
[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Molecules 9(6) , 405-26, (2004)
In the past decade there has been a significant growth in the sales of pharmaceutical drugs worldwide, but more importantly there has been a dramatic growth in the sales of single enantiomer drugs. Th...
Rat liver microsomal metabolism of 2-halogenated 4-methylanilines.Xenobiotica 22(12) , 1403-23, (1992)
1. Rat liver microsomal metabolism of 2-fluoro-, 2-chloro- and 2-bromo-4-methylaniline was investigated using h.p.l.c. Metabolites identified include products from side-chain C-hydroxylation (benzyl a...
Indoline derivatives as 5-HT(2C) receptor agonists.Bioorg. Med. Chem. Lett. 14 , 2367-2370, (2004)
A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are descr...