2-Bromo-4-fluoro-1-methoxybenzene

[Description]:

[Related Catalog]:

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
273.6±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₆BrFO

[ Molecular Weight ]:
205.02

[ Flash Point ]:
98.3±0.0 °C

[ Exact Mass ]:
203.958603

[ PSA ]:
9.23000

[ LogP ]:
2.82

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.519

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2909309090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate.

J. Org. Chem. 78(12) , 5955-63, (2013)

An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a ratio...

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