Alisol F 24-acetate

Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC50 values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research[1][2].

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

Alisol F 24-acetate (5、10 和 20 µM；24 h) 在 MCF-7/DOX 细胞中以剂量依赖性方式增加了阿霉素 (Doxorubicin，HY-15142A) 的化学敏感性[2]。 Alisol F 24-acetate (5、10 和 20 µM) 在 MCF-7/DOX 细胞中以剂量依赖性方式增加了阿霉素的积累。Alisol F 24-acetate (10 µM) 在 Caco-2 细胞单层中增加了地高辛 (Digoxin，HY-B1049) 的吸收 (AP-BL)，降低了地高辛的分泌 (BL-AP)[2]。 Cell Viability Assay[2] Cell Line: Caco-2 cells and MCF-7/DOX cells. Concentration: 1, 2, 5, 10, 20, 50 and 100 µM. Incubation Time: 24 h. Result: Significantly inhibited the cell viability (100 µM). Apoptosis Analysis[2] Cell Line: MCF-7/DOX cells. Concentration: 5, 10 and 20 µM. Incubation Time: 0.5, 1, 2, 3 and 4 h. Result: Promoted the doxorubicin-induced apoptosis with time and dose dependent manner.

[1]. Jiang ZY, et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis. Planta Med. 2006 Aug;72(10):951-4.  

[2]. Pan G, et al. Alisol F 24 Acetate Enhances Chemosensitivity and Apoptosis of MCF-7/DOX Cells by Inhibiting P-Glycoprotein-Mediated Drug Efflux. Molecules. 2016 Feb 4;21(2):183.