- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Alisol F 24-acetate
- Price: ￥2748.0/5mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
443683-76-9
443683-76-9 structure
- Name: Alisol F 24-acetate
- Chemical Name: Alisol F 24-acetate
- CAS Number: 443683-76-9
- Molecular Formula: C32H50O6
- Molecular Weight: 530.736
- Catalog: Signaling Pathways Anti-infection HBV
- Create Date: 2018-06-29 10:17:05
- Modify Date: 2024-01-03 17:44:51
-
Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC50 values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research[1][2].
| Name | Alisol F 24-acetate |
|---|---|
| Synonyms |
(8alpha,9beta,11beta,14beta,23S,24R)-24-(Acetyloxy)-16,23-epoxy-11,25-dihydroxy-dammar-13(17)-en-3-one
Dammar-13(17)-en-3-one, 24-(acetyloxy)-16,23-epoxy-11,25-dihydroxy-, (8α,9β,11β,14β,16β,23S,24S)- (8α,9β,11β,14β,16β,23S,24S)-11,25-Dihydroxy-3-oxo-16,23-epoxydammar-13(17)-en-24-yl acetate |
| Description | Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC50 values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Alisol F 24-acetate (5、10 和 20 µM；24 h) 在 MCF-7/DOX 细胞中以剂量依赖性方式增加了阿霉素 (Doxorubicin，HY-15142A) 的化学敏感性[2]。 Alisol F 24-acetate (5、10 和 20 µM) 在 MCF-7/DOX 细胞中以剂量依赖性方式增加了阿霉素的积累。Alisol F 24-acetate (10 µM) 在 Caco-2 细胞单层中增加了地高辛 (Digoxin，HY-B1049) 的吸收 (AP-BL)，降低了地高辛的分泌 (BL-AP)[2]。 Cell Viability Assay[2] Cell Line: Caco-2 cells and MCF-7/DOX cells. Concentration: 1, 2, 5, 10, 20, 50 and 100 µM. Incubation Time: 24 h. Result: Significantly inhibited the cell viability (100 µM). Apoptosis Analysis[2] Cell Line: MCF-7/DOX cells. Concentration: 5, 10 and 20 µM. Incubation Time: 0.5, 1, 2, 3 and 4 h. Result: Promoted the doxorubicin-induced apoptosis with time and dose dependent manner. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 634.3±55.0 °C at 760 mmHg |
| Molecular Formula | C32H50O6 |
| Molecular Weight | 530.736 |
| Flash Point | 195.8±25.0 °C |
| Exact Mass | 530.360718 |
| LogP | 4.54 |
| Vapour Pressure | 0.0±4.2 mmHg at 25°C |
| Index of Refraction | 1.552 |