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CCT-031374

Names

[ CAS No. ]:
442535-46-8

[ Name ]:
CCT-031374

[Synonym ]:
2-(1,2-dihydroimidazo[1,2-a]benzimidazol-4-yl)-1-(4-phenylphenyl)ethanone
Ethanone, 1-[1,1'-biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)-
1-(4-Biphenylyl)-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone
MFCD01055171
1-Biphenyl-4-yl-2-(2,3-dihydro-1,3a,8-triaza-cyclopenta[a]inden-8-yl)-ethanone
1-(biphenyl-4-yl)-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone

Biological Activity

[Description]:

CCT-031374 is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM; prevents BIO-induced accumulation of β-catenin, does not alter β-catenin levels but blocks transcription at the β-catenin level; also shows activity against endogenous LEF-1 mRNA levels in human neurogenic embryoid bodies (hNEBs) in which Wnt signaling had been induced by BIO.

[References]

References 1. Ewan K, et al. Cancer Res. 2010 Jul 15;70(14):5963-73. 2. Yang Y, et al. Neuroscience. 2013 Sep 17;248:383-91. 3. Liu B, et al. Int J Mol Med. 2015 Dec;36(6):1572-82. View Related Products by Target Beta-catenin

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
557.9±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H19N3O

[ Molecular Weight ]:
353.417

[ Flash Point ]:
291.2±30.7 °C

[ Exact Mass ]:
353.152802

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.683

Related Compounds