m-PEG6-thiol

Names

[ CAS No. ]:
441771-60-4

[ Name ]:
m-PEG6-thiol

[Synonym ]:
3,6,9,12,15,18-hexaoxanonadecane-1-thiol

Biological Activity

[Description]:

m-PEG6-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.057

[ Molecular Formula ]:
C₁₃H₂₈O₆S

[ Molecular Weight ]:
312.42300

[ Exact Mass ]:
312.16100

[ PSA ]:
94.18000

[ LogP ]:
0.64560

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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