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O-2093

Names

[ CAS No. ]:
439080-01-0

[ Name ]:
O-2093

[Synonym ]:
5,8,11,14-Eicosatetraenamide, N,N-bis[(3-chloro-4-hydroxyphenyl)methyl]-, (5Z,8Z,11Z,14Z)-
(5Z,8Z,11Z,14Z)-N,N-Bis(3-chloro-4-hydroxybenzyl)icosa-5,8,11,14-tetraenamide
(5Z,8Z,11Z,14Z)-N,N-Bis(3-chloro-4-hydroxybenzyl)-5,8,11,14-icosatetraenamide

Biological Activity

[Description]:

O-2093 is a selective endocannabinoid anandamide (AEA) reuptake inhibitor with IC50 of 17.3 μM[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[In Vivo]

O-2093 (1 mg/kg, i.v.) 可显着抑制 CREATE 小鼠的肢体痉挛[1]。

[References]

[1]. Alessia Ligresti, et al. New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
715.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C34H43Cl2NO3

[ Molecular Weight ]:
584.62

[ Flash Point ]:
386.3±32.9 °C

[ Exact Mass ]:
583.262024

[ LogP ]:
9.69

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.579

Related Compounds