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TRAF-STOP inhibitor 6877002

Names

[ CAS No. ]:
433249-94-6

[ Name ]:
TRAF-STOP inhibitor 6877002

[Synonym ]:
(2E)-3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
2-Propen-1-one, 3-[(2,5-dimethylphenyl)amino]-1-phenyl-, (2E)-

Biological Activity

[Description]:

TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Apoptosis >> TNF Receptor

[Target]

CD40-TRAF6 interaction; NF-κB


[References]

[1]. Seijkens TTP, et al. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
378.6±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H17NO

[ Molecular Weight ]:
251.323

[ Flash Point ]:
133.5±28.0 °C

[ Exact Mass ]:
251.131012

[ LogP ]:
3.83

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.619

Safety Information

[ Symbol ]:

GHS09

[ Hazard Statements ]:
H411

[ Precautionary Statements ]:
P273-P391-P501

[ Hazard Codes ]:
N

[ RIDADR ]:
UN 3077 9 / PGIII

Related Compounds