[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Names
[ CAS No. ]:
425-51-4
[ Name ]:
[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
[Synonym ]:
6,7-Dehydro-17Alpha-acetoxy Progesterone
17-Hydroxypregna-4,6-diene-3,20-dione acetate
6-Methyl-17alpha-acetoxypregna-4,6-diene-3,20-dione
Melengestro acetate
17-acetoxy-pregna-4,6-diene-3,20-dione
Megestil
Chemical & Physical Properties
[ Density]:
1.16g/cm3
[ Boiling Point ]:
504.7ºC at 760mmHg
[ Molecular Formula ]:
C23H30O4
[ Molecular Weight ]:
370.48200
[ Flash Point ]:
218.7ºC
[ Exact Mass ]:
370.21400
[ PSA ]:
60.44000
[ LogP ]:
4.18520
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU4067000
- CHEMICAL NAME :
- Pregna-4,6-diene-3,20-dione, 17-hydroxy-, acetate (ester)
- CAS REGISTRY NUMBER :
- 425-51-4
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C23-H30-O4
- MOLECULAR WEIGHT :
- 370.53
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 25 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - other measures of fertility
- REFERENCE :
- ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,17,1963
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 25 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - other measures of fertility
- REFERENCE :
- ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,3,1963
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- 13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961