[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate

Modify Date: 2025-09-08 15:11:27

[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate structure	Common Name	[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
	CAS Number	425-51-4	Molecular Weight	370.48200
	Density	1.16g/cm3	Boiling Point	504.7ºC at 760mmHg
	Molecular Formula	C₂₃H₃₀O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	218.7ºC

Name	[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Synonym	More Synonyms

Density	1.16g/cm3
Boiling Point	504.7ºC at 760mmHg
Molecular Formula	C₂₃H₃₀O₄
Molecular Weight	370.48200
Flash Point	218.7ºC
Exact Mass	370.21400
PSA	60.44000
LogP	4.18520
InChIKey	URXWVWVPMJSAJD-KOORYGTMSA-N
SMILES	CC(=O)OC1(C(C)=O)CCC2C3C=CC4=CC(=O)CCC4(C)C3CCC21C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4067000

CHEMICAL NAME :: Pregna-4,6-diene-3,20-dione, 17-hydroxy-, acetate (ester)

CAS REGISTRY NUMBER :: 425-51-4

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H30-O4

MOLECULAR WEIGHT :: 370.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 25 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - other measures of fertility

REFERENCE :: ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,17,1963

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 25 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - other measures of fertility

REFERENCE :: ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,3,1963

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: 13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961

(8R,9S,10R,13S,...

CAS#:4134-58-1

~99%

[(8R,9S,10R,13S...

CAS#:425-51-4

Literature: Boehringer Ingelheim International GmbH Patent: EP1359154 A1, 2003 ; Location in patent: Page/Page column title page; 4; 17; 25; 30; 32 ;

17-(Acetyloxy)-...

CAS#:1054-64-4

[(8R,9S,10R,13S...

CAS#:425-51-4

Literature: Yasuda,K. Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, p. 1167 - 1174

Precursor 2
CAS#:4134-58-1 (8R,9S,10R,13S,... CAS#:1054-64-4 17-(Acetyloxy)-...
DownStream 0

6,7-Dehydro-17Alpha-acetoxy Progesterone

17-Hydroxypregna-4,6-diene-3,20-dione acetate

6-Methyl-17alpha-acetoxypregna-4,6-diene-3,20-dione

Melengestro acetate

17-acetoxy-pregna-4,6-diene-3,20-dione

Megestil

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[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate

Names

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.