1,6-Bis(mesyloxy)hexane

Names

[ Name ]:
1,6-Bis(mesyloxy)hexane

[Synonym ]:
1,6-hexanediyl dimethanesulfonate
Hexane dimethanesulphonate
hexamethylene dimesylate
CTK8I7029
1,6-Bis(mesyloxy)hexane
hexane-1,6-diyl bis[methanesulfonate]
1,6-bis-methanesulfonyloxy-hexane
1,6-hexyl dimesylate
1,6-Hexanediol,dimethanesulfonate
AC1L3RSR
Hexasulphan
1,6-Bis-methansulfonyloxy-hexan
Hexasulfan

Biological Activity

[Description]:

16-Bismesyloxyhexane is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.273g/cm3

[ Boiling Point ]:
474.6ºC at 760 mmHg

[ Molecular Formula ]:
C₈H₁₈O₆S₂

[ Molecular Weight ]:
274.35500

[ Flash Point ]:
240.8ºC

[ Exact Mass ]:
274.05400

[ PSA ]:
103.50000

[ LogP ]:
2.66080

[ Index of Refraction ]:
1.471

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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