Z-Tyr-Val-Ala-Asp-chloromethylketone

Names

[ CAS No. ]:
402474-85-5

[ Name ]:
Z-Tyr-Val-Ala-Asp-chloromethylketone

[Synonym ]:
(5S,8S,11S,14S)-14-(Chloroacetyl)-3,6,9,12-tetrahydroxy-5-(4-hydroxybenzyl)-8-isopropyl-11-methyl-1-phenyl-2-oxa-4,7,10,13-tetraazahexadeca-3,6,9,12-tetraen-16-oic acid
2-Oxa-4,7,10,13-tetraazahexadeca-3,6,9,12-tetraen-16-oic acid, 14-(2-chloroacetyl)-3,6,9,12-tetrahydroxy-5-[(4-hydroxyphenyl)methyl]-11-methyl-8-(1-methylethyl)-1-phenyl-, (5S,8S,11S,14S)-

Biological Activity

[Description]:

Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> Caspase

[Target]

caspase-1, caspase-3[1]


[References]

[1]. Knies UE, et al. Regulation of endothelial monocyte-activating polypeptide II release by apoptosis. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12322-7.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
844.4±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H37ClN4O9

[ Molecular Weight ]:
633.09

[ Flash Point ]:
464.5±37.1 °C

[ Exact Mass ]:
632.224915

[ LogP ]:
6.72

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.601

Related Compounds

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