alizarin complexone

Names

[ Name ]:
alizarin complexone

[Synonym ]:
2-[carboxymethyl-[(3,4-dihydroxy-9,10-dioxoanthracen-2-yl)methyl]amino]acetic acid
Alizarin-3-methylimino-N,N-diacetic Acid
Glycine, N-(carboxymethyl)-N-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]-
Alizarin-3-methyliminodiacetic acid
3,4-Dihydroxyanthraquinon-2-yl-methylimino-diacetic acid
EINECS 223-544-2
MFCD00001202
Alizarin complexone
1,2-Dihydroxyanthraquinonyl-3-methylamine-N,N-diacetic Acid
2,2'-{[(3,4-Dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenyl)methyl]imino}diacetic acid
2,2'-{[(3,4-Dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl]imino}diacetic acid
Alizarin Fluorine Blue

Biological Activity

[Description]:

Alizarin complexone is a calcium-tracer and a chelating agent. Alizarin complexone is Rous-associated virus 2 reverse transcriptase (RAV-2 RT) inhibitor[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[References]

[1]. Higuchi H, et al. Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase. Antiviral Res. 1991;15(3):205-216.

[2]. Oshima T, et al. Selective extraction of histidine derivatives by metal affinity with a copper(II)-chelating ligand complex in an aqueous two-phase system. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;990:73-79.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
687.1±55.0 °C at 760 mmHg

[ Melting Point ]:
~185 °C (dec.)

[ Molecular Formula ]:
C₁₉H₁₅NO₈

[ Molecular Weight ]:
385.324

[ Flash Point ]:
369.4±31.5 °C

[ Exact Mass ]:
385.079773

[ PSA ]:
152.44000

[ LogP ]:
3.38

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.720

[ Stability ]:
Incompatible with strong oxidizing agents.

[ Water Solubility ]:
Slightly soluble (0.2 g/L)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH0585000

CHEMICAL NAME :: Acetic acid, (((3,4-dihydroxy-2-anthraquinonyl)methyl)imino)di-

CAS REGISTRY NUMBER :: 3952-78-1

BEILSTEIN REFERENCE NO. :: 2190028

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H15-N-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,180,1972

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AH0585000

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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