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Climbazole

Names

[ CAS No. ]:
38083-17-9

[ Name ]:
Climbazole

[Synonym ]:
2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-
Crinipan AD
1-(4-chlorophenoxy)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-one
CLIMBAZOL
1-(4-chloro-phenoxy)-1-imidazol-1-yl-3,3-dimethyl-butan-2-one
1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone
(RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
MFCD00055505
1-(4-Chlorphenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-on
baypival
rac-(1R)-1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one
1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one
RadixAsteris
EINECS 253-775-4
1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone
bay-e6975
1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone
1-(p-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone
BAYSAN
Diadimefon
Climbazole

Biological Activity

[Description]:

Climbazole is a topical antifungal agent, commonly used in the treatment of human fungal skin infections, such as dandruff and eczema.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal
Research Areas >> Infection

[Related Small Molecules]

Cycloheximide | Hygromycin B | Cancidas | 5-Flucytosine | Posaconazole | Terbinafine | Ciclopirox | Isavuconazole | Anidulafungin | Clotrimazole | Clioquinol | Miconazole Nitrate | Pimaricin | Ascomycin | Econazole (nitrate)

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
447.5±40.0 °C at 760 mmHg

[ Melting Point ]:
96-100°C

[ Molecular Formula ]:
C15H17ClN2O2

[ Molecular Weight ]:
292.761

[ Flash Point ]:
224.4±27.3 °C

[ Exact Mass ]:
292.097870

[ PSA ]:
44.12000

[ LogP ]:
3.25

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.561

[ Storage condition ]:
-20°C Freezer

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EL7085000
CHEMICAL NAME :
2-Butanone, 1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-
CAS REGISTRY NUMBER :
38083-17-9
BEILSTEIN REFERENCE NO. :
0618020
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C15-H17-Cl-N2-O2
MOLECULAR WEIGHT :
292.79
WISWESSER LINE NOTATION :
T5N CNJ AYOR DG&VX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,832,1986

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H410

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
60-61

[ RIDADR ]:
UN 3077

[ RTECS ]:
EL7085000

[ HS Code ]:
2933290012

Precursor & DownStream

Customs

[ HS Code ]: 2933290012

[ Summary ]:
2933290012 1-((2-chlorophenyl)diphenylmethyl)-1h-imidazole。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Articles

Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole.

Int. J. Cosmet. Sci. 35(1) , 78-83, (2013)

Dandruff is a common complaint and is suffered by as much as half of the population at some time post puberty. The condition is characterized by the presence of flakes on the scalp and in the hair, an...

Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff.

Int. J. Cosmet. Sci. 33(3) , 276-82, (2011)

Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti-dandruff shampoo not only has to provide superior anti-dandruff relief to ensure patient compliance. It als...

[Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography].

Wei Sheng Yan Jiu 34(5) , 626-8, (2005)

A high performance liquid chromatography method was established for determination of antidangdruff agent salicylic acid,zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo on a C18 colu...


More Articles


Related Compounds

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